Do cancer cells specifically develop resistance to chemotherapy drugs and if they do explore potential treatment options that slow the growth of cancer .

The reason it is important to research this topic is because as of 2022 “there were an estimated 20 million new cancer cases and 9.7 million deaths. The estimated number of people who were alive within 5 years following a cancer diagnosis was 53.5 million. About 1 in 5 people develop cancer in their lifetime, approximately 1 in 9 men and 1 in 12 women die from the disease”. Just by looking at these Numbers you can clearly see the severity of cancer by researching topics such as this we are able to further look a issues that are arising and finding solutions to combat them, in this case I’ll be researching how cancer cells develop resistance to chemotherapy drugs and explore potential strategies to overcome this resistance.

The way I'm researching this topic is firstly obviously by going to reliable sources that specialize in cancer or cancer research as well as I am also not going to be using Wikipedia for the soul factor that a lot of people think of as an untrustworthy site. I want to use trustworthy sites to get clear information. I will also be talking to some professionals to get their professional opinion on it as well as using government issues sites because those are more reliable than say for example some like unknown hospitals I am still going to be looking at hospitals some more well-known so Alberta Hospital Children's Hospital AHS all of these different types of hospitals that are reputable I will see looking at University papers and other various places and sources because it's best that you cross-reference everything so that you get the most out of information.

Do cancer cells specifically develop resistance to chemotherapy drugs and if they do explore potential treatment options that slow the growth of cancer?

The textbook definition of resistance in the medical field is “(reh-ZIH-stunts) When cancer cells or microorganisms, such as bacteria or viruses, don't respond to a drug that is usually able to kill or weaken them. Drug resistance may be present before treatment is given or may occur during or after treatment with the drug.” while this statement is true resistance is sometimes not the issue a statement taken from Dr.Zoya states “Sometimes it isn't resistance that's the issue sometimes it's how aggressive to cancer, for example, lung cancer is more aggressive and harder to treat because it spreads so quickly whereas Carcinoid tumours are slower and take more time for it to grow sometimes we even say a patient will outlive Their cancer before it becomes harmful”.

Intrinsic resistance is “Resistance can occur when cancer cells—even a small group of cells within a tumour—contain molecular changes that make them insensitive to a particular drug before treatment even begins. ” This statement explains that this type of resistance happens before any treatment where the cells don’t respond and never did. 

Developed resistance is when over time the cells stop responding to the treatment.

“Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemotherapy resistance can arise due to several host or tumour-related factors.” This means that at one point this treatment was working but slowly over time the cancer acquired the ability to resist treatment 

Chemotherapy is when you use powerful chemicals to slow and kill cancer cells.”Chemotherapy works by stopping or slowing the growth of cancer cells, which grow and divide quickly. Chemotherapy is used for two reasons: Treat cancer: Chemotherapy can be used to cure cancer, lessen the chance it will return, or stop or slow its growth”. This statement explains perfectly how chemotherapy works the main focus is how chemotherapy can stop and or slow the growth.

Cancer starts to develop when issues in the process where DNA is terminating stuff such as the structures,function,and behavior of the cell occur. When the DNA gets damaged during this process and gets mutated, and mutated cells don’t work properly, cells that should be resting divide and grow rapidly, further causing a tumor. 

It is extremely important to talk about how cost-effective a treatment is because it helps us weigh the cost of a new treatment. It's also important to recognize that cancer is pretty cost-effective in terms of treatment. This is because when we are looking at how cost-effective something is, we are not looking at how expensive a treatment is but instead achieving the desired outcome as cheaply as possible.

in conclusion, cancer does develop a resistance to some chemotherapy drugs and some of the best ways to combat it are alternative treatments which would include the following

1] Radiotherapy has two main types, the first one is external beam radiation therapy and the second one is internal radiation both works by destroying cancer cell DNA, which leads to cancer cells not having the proper instructions to profilate this intern leads to cell death. Overall even though there is resistance you are 90% less likely to develop resistance to radiotherapy compared to chemotherapy

2] targeted therapy, which has 2 common types. 1 being monoclonal antibodies and number 2 being small molecule inhibitors. Monoclonal antibodies target certain proteins, most often being receptors on the cancer cell surface or in the microenvironment. Small molecule inhibitors that pass through a cell's surface to intracellular targets to slow the proflarationor cause cell death.

https://docs.google.com/document/d/1f1SqGkfiuy5QcYm06OMk6o7Mc1WJNjFk2LWPhBYpih8/edit?usp=sharing

https://docs.google.com/document/d/1-kAo61eWkf3XTHbTUVM4xjPYsEoRfqLnbRLMqSnm1fE/edit?usp=sharing

Dr. Zoya Khan- Family Doctor who deals with helping her patients get cancer treatment 

Dr. Jeena Loranda- Practicing nurse who helps cancer patients recover after having cancer treatment as well as testing for cancer 

AHS- For supplying me with amazing websites and feedback    

Mr.Z- Old coordinator who gave medical insight and termanology from past career  

Ms.Offord- New coordinator who provided materials to succeed  

Ms.Petrovic- Helped achieve scholarly sources  

 NIH- Gave amazing and credible information

Ayomide- One of my fellow participants  (feedback)

Reynah- One of my fellow participants    (feedback)